Abstract
Eight cycloartane-type triterpene glycosides ( 1– 8) were isolated from Astragalus aureus Willd along with ten known cycloartane-type glycosides ( 9– 18). Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analyses. Compounds 1– 5 are cyclocanthogenin glycosides, whereas compounds 6– 8 are based on cyclocephalogenin as aglycon, more unusual in the plant kingdom, so far reported only from Astragalus spp. Moreover, for the first time monoglycosides of cyclocanthogenin ( 5) and cyclocephalogenin ( 7, 8) are reported. All of the compounds tested for their cytotoxic activities against a number of cancer cell lines. Among the compounds, only 8 exhibited activity versus human breast cancer (MCF7) at 45 μM concentration.
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