Abstract
We have determined the crystal structures of two diketopiperazines, cyclo(l-alanyl-l-seryl).H2O, (cis-6-hydroxymethyl-3-methyl-2,5- piperazinedione hydrate, C6H10N2O3.H2O and cyclo(glycyl-l-seryl), 3-hydroxymethyl-2,5-piperazinedione, C5H8N2O3. The crystal structure of cyclo(l-alanyl-l-seryl).H2O [cyclo(l-Ala-l-Ser)] consists of a peptide backbone that is hydrogen bonded to two adjacent diketopiperazine rings, forming extended chains through the crystal. The serine hydroxyl of cyclo(l-Ala-l-Ser) is hydrated by two adjacent water molecules in the crystal. In contrast, the crystal structure of cyclo(Glycyl-l-seryl) [cyclo(Gly l-Ser)] is held together by a three-dimensional network of hydrogen bonds. The serine hydroxyl of cyclo(Gly l-Ser) participates in two hydrogen bonds with the peptide backbone of neighboring molecules.
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