Abstract
In the present work some of 1,2,3-selenadiazole compounds derived from corresponding semicabazones have been prepared. The reaction of substituted chalcone compounds (1a-c) and 4-methoxy benzyl cyanide give compounds (2a-c) which were converted through the reaction with semicarbazide hydrochloride into the corresponding semicarbazones (3a-d(. The treatment of these compounds with selenium dioxide leads to ring closure of semicarbazones to give the 1,2,3-selenadiazole compounds. The structures of the synthesized compounds were established by physical and spectral methods.
Highlights
In the last years heterocyclic compounds containing selenium atom are of considerable chemical and biochemical interest due to their synthetic and biological applications, they are similar in chemical and physical properties with the corresponding organo-sulfur compounds but not identical in bond stability [1,2,3]
Selenium compounds are less stable on exposure to light or heat and are more oxidized than their sulfur analogous due to the larger size of the selenium atom and an increased in polarizability, they are in general, less stable than the corresponding sulfur analogues[4]
Some aspects of the metabolism of organo-sulfur compounds resemble those of their sulfur analogous, their metabolic pathways diverge considerably
Summary
In the last years heterocyclic compounds containing selenium atom are of considerable chemical and biochemical interest due to their synthetic and biological applications, they are similar in chemical and physical properties with the corresponding organo-sulfur compounds but not identical in bond stability [1,2,3]. The produced precipitate was filtered off ,washed with cooled water and recrystallized from ethanol .The physical and spectral data are given in Table [1].
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