Abstract
6-N-Substituted 6-amino-8-methylpurines and 6-amino-8-methyl-9-substituted purines were obtained by cyclization of 6-N-substituted 4,5,6-triaminopyrimidines with acetic acid imino ester hydrochloride. The yields of the isomers depend on the different basicities of the secondary amino groups, which are determined by the basicities of the starting amines. The yields of the 6-amino-8-methyl-9-substituted purines increase with decreasing basicity.
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