Abstract
AbstractVarious 2‐alkynylallyl alcohols were synthesized by a generally applicable Sonogashira coupling protocol. Subsequent gold‐catalyzed transformation was investigated. The use of AuI catalysts bearing carbene ligands, of either the N‐heterocyclic carbene or nitrogen acyclic carbene type, delivered the desired products with low catalyst loadings and under very mild reaction conditions. A broad array of substrates was tested, including alkyl‐, alkenyl‐, and aryl‐substituted alkynes, as well as substrates with two alkynyl moieties. The methodology turned out to have a broad scope. Secondary allyl alcohols were also tolerated, and the resulting trisubstituted furans could be isolated in high yields.
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