Abstract
Cyclin D1in breast cancer is not associated with Ki67 but with ER
Highlights
D-type cyclins are implicated in cell cycle regulation
The cyclin D1 gene is amplified in 15-20% of breast cancers while the protein is overexpressed in 50% of these cancers
Invasive cancers showed a higher percentage of Ki67-positive cells than normal tissue and this was significantly higher in ERnegative than in ER-positive carcinomas
Summary
Cyclin D1, immunohistochemistry, Ki67, normal breast, oestrogen receptor. D-type cyclins are implicated in cell cycle regulation. The cyclin D1 gene is amplified in 15-20% of breast cancers while the protein is overexpressed in 50% of these cancers (see Additional information [1]). Overexpression of cyclin D1 has been linked with oestrogen receptor (ER)a, because it can stimulate transcriptional functions in the absence of oestrogen (see Additional information [2]). A negative association in normal breast has been reported for ERa and Ki67 (a proliferation marker), this relationship changes in many precancerous and ER-positive cancers. The aim of the study was to investigate the interaction between cyclin D1, ER and Ki67 in normal and malignant breast material
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