Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma.

Abstract

Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and the risk for developing MM remains poorly characterized. We performed a case-control study with 67 patients with MM and 66 healthy controls in a Chinese population. The cancer-associated G870A single nucleotide polymorphism (SNP) of CCND1, the gene encoding cyclin D1, was determined by polymerase chain reaction and restriction fragment length polymorphism. We found that there was a strong association between the homozygous variant allele (GG) and MM susceptibility, with an odds ratio (OR) of 4.679 [95% confidence interval (CI): 1.081-5.647]. When further stratified analysis was performed, the increased risk was only evident in individuals over 60 years old (OR=3.297; 95%CI: 1.058-10.276). Our results suggest that the CCND1 G870A SNP may be critically involved in MM development.