Abstract
The junction points of recurring chromosome translocations in hematopoietic tumors have yielded a rich harvest of oncogenes by molecular cloning (Korsmeyer 1992). One such karyotype alteration, the t(11;14) (q13;q32) in certain human B-lymphoid neoplasms, was first described 15 years ago by Vandenberghe et al. (1979), but has only recently yielded a candidate oncogene, cyclin D1. In this paper, we briefly review the path by which the gene was discovered, the clues to its role in progression of the G1 phase of the cell cycle, and the recently published evidence for its tumorigenic activity, including our own analysis of cyclin D1 transgenic mice. For a comprehensive review of cyclins and their possible roles in oncogenesis, see Sheir (1993) and Motokura and Arnold (1993).
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