Abstract
The occurrence of periodic hemorrhages in the I course of prolonged treatment with equal and constant doses of estrogens in castrated women and female monkeys is an important experimental fact in the knowledge of menstruation. Werner and Collier (1) injected castrate women daily with 100 to 300 I.U. of estrone in a watery solution, for a period of several months. Periodic uterine bleeding occurred during the treatment. Hisaw (2), Corner (3) and Zuckerman (4) obtained the same result in castrated female monkeys injected with moderate doses (approximately 100 I.U.) of estrone daily for a year. Bleeding recurred at intervals of 5 to 7 weeks. When Zuckerman repeated the experiment (5) using larger doses of estrone, he found that bleeding did not occur during the period of one year in which the castrate monkey received 1000 I.U. of estrone daily. Bishop (6) described ‘threshold’ bleeding which occurred periodically in a castrate woman receiving 5000 to 6000 I.U. of estrone.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Clinical Endocrinology & Metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
