Cyclic Targetoid Rash With Menstruation

Abstract

A 41-year-old woman had a 5-year history of targetoid purpuric-red plaques on the legs at a menstrual cycle interval. The eruption predictably started 5 to 7 days before menstruation and resolved within several days after cessation of menses. She had no history of menstrual irregularity or other comorbidities. There was no history of intake of exogenous progesterone. On physical examination, there were multiple targetoid plaques with purpuric-red color on the leg (Figure 1). Skin specimen showed parakeratosis, spongiotic microvesicle, upper dermal edema, and perivascular infiltration of inflammatory cells (Figure 2).