Cyclic systems in drug synthesis

Abstract

This chapter explores cyclic systems in drug synthesis. It notes the vital role that cyclic systems play in drug structures which would be referred to as carbocyclic or heterocyclic. Additionally, the chapter notes that the ring systems made up of carbon atoms could can vary in sizes as well. It highlights the importance of ring systems in terms of ensuring binding groups are correctly positioned as ideal scaffolds. The chapter also discusses the two synthetic strategies that would ensure that cyclic structures can be introduced into a drug structure. It notes thediscusses examples of syntheses involving intramolecular cyclisationscyclizations, concerted intermolecular cyclisationscyclizations, intermolecular coupling, and cyclisation cyclization reactions. Moreover, it looks into at the synthesis of dihydropyridines.