Cyclic nucleotides in the brain of mice and rats submitted to the convulsant, methionine sulfoximine

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Regional cyclic AMP and cyclic GMP levels were measured in the rat and mouse brain following intraperitoneal injection of the convulsant methionine sulfoximine (MSO), at a dose of 100 mg/kg body weight. No change in the cyclic AMP content is noticeable in the mouse cerebral cortex and in the rat cerebral cortex, striatum, hypothalamus and cerebellum during the preconvulsive, convulsive and postconvulsive periods following administration of MSO. The cyclic GMP content increases in the mouse cerebral cortex and brain stem, but it does not change in the cerebellum, during the period of MSO-induced seizure activity. At the time of recovery from seizures, the increase of cyclic GMP content persists only in the brain stem. During the whole periconvulsive period cyclic GMP level rises in the brain stem. Administered at a dose of 50 mg/kg body weight, MSO induces a relatively reduced increase of cyclic GMP content in the brain stem only. It is suggested that the increase of the level of cyclic GMP may develop simultaneously in neuronal and glial cells, primarily in the brain stem, during some periods following administration of the convulsant MSO.