Abstract
In adult male C57 black mice, intracortical injection of bicuculline (10 μg) elevated cGMP concentrations and produced contralateral clonic seizures. After intraperitoneal injection, bicuculline (10 mg/kg) elevated cGMP concentrations at the earliest time at which paroxysmal EEG activity could be detected. Changes in cAMP concentration followed those events. Further elevations of cGMP concentrations (and now of cAMP as well) were observed during clonic and tonic seizures. Intracortical injections of dibutyryl cGMP produced behavioral and EEG seizures. These data suggest that cGMP plays an important role in bicuculline seizures.
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