Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids.

Seyeon Park

doi:10.3390/molecules21111556

Abstract

Diverse flavonoids are abundant in dietary food constituents and possess useful biological activities. However, some flavonoids have limited bioavailability due to their low solubility in water. As an important approach to enhance aqueous solubility, inclusion of hydrophobic guest molecules in hydrophilic hosts such as cyclic glucans has been used. This review summarizes applications of β-cyclodextrin, synthetic β-cyclodextrin derivatives, and newly synthesized derivatives of cyclosophoraoses as complexing agents to enhance the bioavailability of flavonoids such as baicalein, kaempferol, and naphthoflavones.

Highlights

Flavonoids are polyphenols that are abundant in dietary food constituents
This paper reviewed the enhanced solubility of flavonoids in complex with cyclic glucans including CD, Cys, and newly synthesized cyclic cyclic glucans glucans (Figure (Figure 2)
Changing guest molecular properties after formation of inclusion complexes has led to many applications of cyclic glucans in pharmaceuticals, cosmetics, and food industries [53]

Summary

Introduction

Flavonoids are polyphenols that are abundant in dietary food constituents. They are abundant in numerous groups of natural products such as fruits, vegetables, grains, and nuts. Flavonoids possess a common phenylbenzopyrone structure (C6-C3-C6) Several cyclic glucans have received attention because of their potential as carriers These compounds consist of glucose monomers arranged in a toroidal ring. Cyclodextrins (CDs) are a family of macrocyclic oligosaccharides known as α, β, and γ-CD (composed of 6-, 7-, and 8-α-(1,4) linked glycosyl units, respectively) These compounds have a characteristic cone-shaped and internally truncated cavity. Cys derivatives derivatives could synthesized by substitution of various various functional functional groups groups such such as methyl, hydroxypropyl, hydroxypropyl, carboxymethyl, carboxymethyl, and and sulfate substitution of groups They have been used as hosts of inclusion complex [11].

Structure

Inclusion Complexes of α- and β-Naphthoflavone

Flavonol and β-cyclodextrin

Solubility

Practical Application

Conclusions