Abstract
In the second messenger concept, adenylate cyclase and its hormonal receptors translate specific extracellular signals into intracellular cyclic adenosine 3′:5′-monophosphate (cyclic AMP) production. Cyclic AMP, in turn, interacts with the regulatory subunits of protein kinase, and also is degraded into 5’-AMP by cyclic nucleotide 3’:5’-phosphodiesterase (phosphodiesterase) (1). For these reasons it is common to use measurements of adenylate cyclase activities and phosphodiesterase activities in cell-free preparations as indicators of the kinetics of cyclic AMP metabolism in intact cells. Alternatively, the accumulation of cyclic AMP in intact cells often is viewed as a measure of the rate of intracellular production and destruction of cyclic AMP. In this report we would like to discuss these notions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
