Abstract
The level of adenylate cyclase (AC) and phosphodiesterase (PDE) activity and the reserves of cyclic AMP in the liver of newborn rats were investigated in normal animals and after irradiation on the 9th day of embryonic development. After irradiation in a dose of 50 R the basal AC and PDE activity was reduced, but there was no change in the steady-state cyclic AMP content in the tissues. The adrenalin-stimulated AC activity showed only a tendency to fall after irradiation. It is suggested that at critical moments of development, when the hormonal inducer is present in the liver of irradiated animals the conditions may be created for an increase in the cyclic AMP reserves.
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