Abstract
Serum free media, prostaglandin E 1 and inhibitors of cyclic nucleotide phosphodiesterase stimulate axon formation of mouse neuroblastoma cells grown in culture. These agents are shown here to also increase the basal cellular level of cyclic AMP supporting the hypothesis that cyclic AMP may be an important molecule in the differentiation process. Several inhibitors of macromolecular synthesis and assembly were examined for any effect on the neuroblastoma cell's basal or stimulated cyclic AMP level. Cycloheximide, an inhibitor of protein synthesis was observed to depress cAMP levels suggesting that protein synthesis is necessary for the maintenance of the basal cellular cyclic AMP level. Results from experiments using combinations of agents which stimulate axon formation and the inhibitors of macromolecular synthesis and assembly further support a possible relationship between cyclic AMP and the morphological differentiation of neuroblastoma.
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