Abstract
Samples of normal human cerebellar and cerebral cortex have been tested in vitro with histamine, serotonin and norepinephrine and the formation of cyclic adenosine-3'5'-monophosphate (cAMP) has been measured. Only norepinephrine exerts a clearly stimulating effect on cAMP formation in both tissues. In this respect, human brain cyclase resembles more that of the rat than the monkey, which does not respond to norepinephrine.
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