Cyclic AMP dependent protein kinase and its endogenous inhibitor protein: tissue distribution and effect of vitamin D status in the chick

Abstract

1. 1. Vitamin D deficiency in the chick leads to decreased (to 55% of normal) cyclic AMP-dependent protein kinase activity in the kidney but does not alter calcium-dependent phospholpid-sensitive protein kinase activity. 2. 2. Decreased cyclic AMP-dependent protein kinase activity in response to vitamin D deficiency was not observed in other tissues including pancreas, brain, liver, intestinal mucosa, or heart. 3. 3. Vitamin D deficiency leads to elevated levels of the endogenous inhibitor protein of cyclic AMP-dependent protein kinase in kidney, but not heart, muscle, pancreas, or brain.