Abstract
Arresting P815 mastocytoma cell growth with N 6, O 2′-dibutyryladenosine 3′:5′ cyclic monophosphate (db cAMP) and theophylline increased 45Ca 2+ uptake and efflux by the cells (i.e., Ca 2+ cycling) without altering cytoplasmic free Ca 2+ concentrations or the amount or distribution of protein kinase C in the cells. Attempts to identify the Ca 2+ channels involved using a wide variety of drugs were unsuccessful. However, the inhibitory effect of db cAMP on growth was greatly increased in medium containing low Ca 2+ concentrations, confirming that interactions between Ca 2+ and cyclic AMP can affect mastocytoma cell growth.
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