Abstract
There is a significant increase in hepatic cAMP binding activity 4 hr following ethionine intoxication. This activity is localized to the 100,000 g supernatant. The binding of cAMP by the 100,000 g supernatant of controls can be increased to experimental levels simply by dialysis. The increased binding activity seen during ethionine intoxication can be reversed by the administration of adenine. Neither S-adenosyl ethionine, S-adenosyl methionine, S-adenosyl homocysteine, nor AMP compete effectively with cAMP for the binding protein. Increasing ADP concentrations stimulates cAMP binding whereas increasing ATP concentration inhibits cAMP binding. At concentrations seen during ethione intoxication the effects of ADP and ATP were equal but opposite in direction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
