Abstract
Mediation of the catecholamine relaxing effect in uterine smooth muscle by cyclic AMP was suggested in our previous reports (1, 2). Further experimental work confirmed this and indicated that cyclic AMP has an even broader role in the regulation of smooth muscle function (2): compounds inhibiting cyclic AMP phosphodiesterase and thereby increasing intracellular cyclic AMP, consequently relax the smooth muscle (3); they also potentiate the relaxing effect of compounds which stimulate adenyl cyclase (2). Other compounds, e.g. halothane, acetylcholine, nitroprusside, may also exert part of their functional effects on smooth muscle through the cyclic AMP system. We have shown previously (4) that the cyclic AMP system is present in arterial smooth muscle and is a part of the regulatory mechanism of arterial tone and contractility. The present data add further information about the role of the cyclic AMP system in the control of vascular smooth muscle function.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
