Abstract
LIMB regeneration in the adult newt is dependent on the nervous system1,2 but the biochemical events involved are not well understood. A role for catecholamines (CA) seems likely since histofluorescence has shown that CA are more abundant in regenerates than in other newt limb tissues3. It has also been shown it hat reserpine, which promotes the release of CA from nerve terminals, accelerates regeneration4, whereas chlorpromazine5, guanethidine5 (both CA release blockers) and α-methyl-p-tyrosine6 (CA biosynthesis inhibitor) inhibit it. Studies suggest that in many biological systems the CA effects are linked to the activation of membrane adenylate cyclase with subsequent production of cyclic AMP7. It has also been suggested that nerves may transmit trophic information by the stimulation of this enzyme8–11. To test this hypothesis further, regenerates were isolated either for direct measurements of cyclic AMP or for stimulation with CA in vitro12. This method avoids the possible nonspecific effects due to systemic administration of CA. We now report that the fluctuations of cyclic AMP found at the various stages of regeneration correlate with noradrenaline (NA) sensitivity changes.
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