Abstract
ABSTRACTThe relationship of cyclic AMP to epidermal cell division has been studied in cultured guinea pig epidermal cells. Tritiated thymidine uptake by cultured cells reached a peak the second day after seeding. A significant drop in the concentration of cyclic AMP occurred simultaneously with the increased uptake of tritiated thymidine into DNA. Those cells in which the concentration of cyclic AMP decreased did not respond to external prostaglandin E1 (PGE1) stimulation. The response was restored in the cultured cells on the fourth and fifth when intracellular concentration of cyclic AMP started to rise. The results indicate that there is a cyclic alteration of the surface membrane of epidermal cells during active DNA synthesis which may be related to fluctuation in the intracellular concentration of cyclic AMP.
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