Abstract
Two active peaks of phosphodiesterase, I and II, were resolved by a gel filtration column chromatography of the high speed supernatant of brain extract. The peak II represented Ca ++ plus Mg ++ dependent phosphodiesterase, the occurence of which in the supernatant of brain extract had been reported (1, 3), while the peak I may be called as “Ca ++ independent” and Mg ++ dependent phosphodiesterase from its nature. The former decomposed cyclic AMP, cyclic GMP, and cyclic UMP with the stimulatory effect of Ca ++ion. The latter, decomposing cyclic GMP at the comparable rate to cyclic AMP, showed negligible activity to cyclic UMP.
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