Abstract
Cyanobacteria are responsible for poisoning numerous cases of livestock and other animals, but sometimes they induce serious problems in humans. Mass occurrence and blooms of cyanobacteria were studied in rivers, canals, lakes, and accu?mulations that had been examined in Serbia during period 1980-2002. Because of massive blooming of cyanobacteria, when they produce cyanotoxins, which could be responsible for poisoning, and damage of organs, studies are steered to better understanding cyanotoxins effects on human health. The investigation on microcystins, as one of many cyanotoxins, is increas?ing due to the related ecological and public health risks. There is evidence that microcystins have a tumor promoting activity and microcystin-LRcould be tumor initiator and possibly cancerogenic to humans. Epidemiological studies have suggested that there is connection between primary liver cancer (PLC) and microcystins, as one of risk factor for high incidence rate of PLC in Serbia.
Highlights
Numerous studies have shown that cyanotoxins could CRC, colorectal carcinoma; Mc-LR, microcystin-LR; PP1, protein have negative effects on animal and human health, and there are many of phosphatase; PP2A, protein epidemiological data and laboratory reports of animal and human poisoning phosphatase 2A; TNF-A, tumor necrosis factor alpha; reactive oxygen species (ROS), reactive with lethal consequences
This paper adverts that there is evidence of liver injury in people who drink water contaminated by cyanobacterial toxins and evidence that microcystins act as tumor promoter in animals
After acute intaperitoneal or intravenous injection of microcystins severe liver damage, intrhepatic hemorrhage, heart failure and death were seen in animals
Summary
Cyanobacteria are responsible for poisoning numerous cases of livestock and other animals, but sometimes they induce Arch Oncol 2008;16(3-4):. The investigation on microcystins, as one of many cyanotoxins, is increas- Sad, Serbia, 2Department of Biology ing due to the related ecological and public health risks. There is evidence that microcystins have a tumor promoting activity and Ecology, Faculty of Sciences, University of Novi Sad, Serbia, and microcystin-LR could be tumor initiator and possibly cancerogenic to humans. Epidemiological studies have suggested 3Oncology Institute of Vojvodina, that there is connection between primary liver cancer (PLC) and microcystins, as one of risk factor for high incidence rate of Sremska Kamenica, Serbia. Correspondence to: 0LUHOD)-XNRYLþ0HGLFDO)DFXOW\ University of Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad, Serbia
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