Abstract
Cyanobacteria are considered to be one of the most promising sources of new, natural products. Apart from non-ribosomal peptides and polyketides, ribosomally synthesized and post-translationally modified peptides (RiPPs) are one of the leading groups of bioactive compounds produced by cyanobacteria. Among these, cyanobactins have sparked attention due to their interesting bioactivities and for their potential to be prospective candidates in the development of drugs. It is assumed that the primary source of cyanobactins is cyanobacteria, although these compounds have also been isolated from marine animals such as ascidians, sponges and mollusks. The aim of this review is to update the current knowledge of cyanobactins, recognized as being produced by cyanobacteria, and to emphasize their genetic clusters and chemical structures as well as their bioactivities, ecological roles and biotechnological potential.
Highlights
Cyanobactins belong to the class of ribosomally synthetized peptides with post-translational modifications (RiPPs) that can be generally defined as cyclic peptides containing modifications, which include azole/azoline rings, D-sterocenters and in some cases, prenyl groups [1].These compounds can be produced by distinct cyanobacteria strains through a pathway recently assigned as post-ribosomal peptide synthesis (PRPS) [2]
This review aims to present the current state of knowledge of cyanobactins, which are produced solely from cyanobacteria, with special emphasis given to their chemical structures, genetic biosynthetic pathways, bioactivities, ecological roles and biotechnological potential
The known peptides derived from L. patella were categorized in two separate groups, one constituted by ulithiacyclamide and patellamides A, B and C and the other represented by ulicyclamide and lissoclinamides 1–3
Summary
Cyanobactins belong to the class of ribosomally synthetized peptides with post-translational modifications (RiPPs) that can be generally defined as cyclic peptides containing modifications, which include azole/azoline rings, D-sterocenters and in some cases, prenyl groups [1]. These compounds can be produced by distinct cyanobacteria strains through a pathway recently assigned as post-ribosomal peptide synthesis (PRPS) [2]. This review aims to present the current state of knowledge of cyanobactins, which are produced solely from cyanobacteria, with special emphasis given to their chemical structures, genetic biosynthetic pathways, bioactivities, ecological roles and biotechnological potential
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