Abstract
Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.
Highlights
Cyanobacteria, whose metabolism has played a unique role in ecosystems since ancient times, have probably been in existence for more the 3.5 billion years [1]
We weare arestudying studying9191 compounds; 63 naturally occurring metabolites and compounds; 63 naturally occurring metabolites and 28 comcompounds synthesized from marine cyanobacteria
According to the best of our pounds synthesized from marine cyanobacteria
Summary
Cyanobacteria, whose metabolism has played a unique role in ecosystems since ancient times, have probably been in existence for more the 3.5 billion years [1]. Symbioses occur between cyanobacteria and other marine organisms such as sponges, ascidians, lichens, dinoflagellates, euchiuroid worms and macroalgae They act as nitrogen fixing agents and releasers of dissolved organic carbon that benefit their hosts, producing defensive specialized metabolites that save their hosts from being attacked by predators. Cyanobacteria have long been known to produce the most efficient chemical defense specialized metabolites from different classes of natural products such as lipopeptides, alkaloids, depsipeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides [22]. For doing so, they used plenty of enzymes, specialized for the biosynthesis of their basic skeletons and tailoring enzymes for their modification [23]. This review presents an overview focusing on the biotechnological applications, therapeutic properties and clinical uses of cyanobacteria and their metabolites in addition to introducing their synthetic bioactive compounds
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
