Cyanobacteria and Red Macroalgae as Potential Sources of Antioxidants and UV Radiation-Absorbing Compounds for Cosmeceutical Applications.

Julia Vega,Juan Luis Gómez-Pinchetti,Félix L Figueroa,José Bonomi-Barufi

doi:10.3390/md18120659

Abstract

In recent years, research on natural products has gained considerable attention, particularly in the cosmetic industry, which is looking for new bio-active and biodegradable molecules. In this study, cosmetic properties of cyanobacteria and red macroalgae were analyzed. The extractions were conducted in different solvents (water, ethanol and two combinations of water:ethanol). The main molecules with antioxidant and photoprotective capacity were mycosporine-like amino acids (MAAs), scytonemin and phenolic compounds. The highest contents of scytonemin (only present in cyanobacteria) were observed in Scytonema sp. (BEA 1603B) and Lyngbya sp. (BEA 1328B). The highest concentrations of MAAs were found in the red macroalgae Porphyra umbilicalis, Gelidium corneum and Osmundea pinnatifida and in the cyanobacterium Lyngbya sp. Scytonema sp. was the unique species that presented an MAA with maximum absorption in the UV-B band, being identified as mycosporine-glutaminol for the first time in this species. The highest content of polyphenols was observed in Scytonema sp. and P. umbilicalis. Water was the best extraction solvent for MAAs and phenols, whereas scytonemin was better extracted in a less polar solvent such as ethanol:dH2O (4:1). Cyanobacterium extracts presented higher antioxidant activity than those of red macroalgae. Positive correlations of antioxidant activity with different molecules, especially polyphenols, biliproteins and MAAs, were observed. Hydroethanolic extracts of some species incorporated in creams showed an increase in the photoprotection capacity in comparison with the base cream. Extracts of these organisms could be used as natural photoprotectors improving the diversity of sunscreens. The combination of different extracts enriched in scytonemin and MAAs could be useful to design broad-band natural UV-screen cosmeceutical products.

Highlights

Solar UV radiation (UVR) comprises UV-C (200–280 nm), UV-B (280–315 nm) and UV-A (315–400 nm), only UV-A and a small part of UV-B reach the Earth’s surface
All of the species evaluated in our study presented a high content of total internal carbon, i.e., most species values were higher than 30% of dry weigh (DW), similar to the average C content obtained in algae [40]
This study shows the usefulness of extracts of different species of cyanobacteria and red macroalgae as cosmeceuticals due to both their antioxidant and photoprotection capacity

Summary

Introduction

Solar UV radiation (UVR) comprises UV-C (200–280 nm), UV-B (280–315 nm) and UV-A (315–400 nm), only UV-A and a small part of UV-B reach the Earth’s surface. UV-B radiation is the most harmful, inducing mutations in the DNA of skin cells, whereas UV-A radiation is indirectly mutagenic by generating reactive oxygen species (ROS) [1,2]. UVR can provoke some clinical effects in humans, such as erythema, pigmentation, immunosuppression, photoaging or carcinogenesis [3,4,5,6]. Mar. Drugs 2020, 18, 659; doi:10.3390/md18120659 www.mdpi.com/journal/marinedrugs. Mar. Drugs 2020, 18, 659 several studies have demonstrated the biological effects of blue light (400–450 nm) in human skin, such as pigmentation, erythema or free radical production [7,8,9]

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