Abstract
<h3>To the Editor.</h3> —We recently described the antibacterial effects of cyanoacrylate glue in the JuneArchives.<sup>1</sup>In that article we reported that enbucrilate (butyl-2-cyanoacrylate; Histoacryl [West Germany], no comparable US product) exhibited bacteriostatic activity against gram-positive organisms but not against gram-negative organisms. Several inexpensive cyanoacrylates are now available from Japan. We tested the antimicrobial effect of ultra-quick-setting methyl cyanocarylate, ultra-quick-setting ethyl cyanoacrylate, quick-setting ethyl cyanoacrylate, and butyl cyanoacrylate. There was no substantial difference among any of these compounds with respect to gram-positive organisms; however, butyl cyanoacrylate showed bacteriostatic activity against<i>Serratia marcescens, Pseudomonas aeruginosa</i>, and<i>Enterobacter aerogenes</i>. We treated two patients with gram-negative ulcers with impending perforation with butyl cyanoacrylate without complications. These compounds may prove to be effective adjunctive treatment in corneal disease.
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