Cyanidin 3‐O‐glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS‐1 Cells by Improving Insulin Secretion and Signaling

Abstract

Cyaniding 3‐O‐glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3‐O‐glucoside on insulin release in INS‐1 cells. L. caerulea extract and cyanidin 3‐O‐glucoside activated the secretion of insulin that lead to diminished glucose production in INS‐1 cells. Cyanidin 3‐O‐glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3‐kinase protein expressions in INS‐1 cells. These results suggest that cyanidin 3‐O‐glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling.