Abstract
ObjectiveTo deeply verify the clinical significance of CXCR3 in prediction of cancer patients’ prognosis.Data sourcesWe performed a meta-analysis including 12 studies searched from PubMed, Web of Science, Embase, and Cochrane databases. A total of 1,751 patients were used to analyze the association between CXCR3 and patients’ prognosis, based on either overall survival or time to tumor progression.Study selectionStudies evaluating CXCR3 expression for predicting prognosis in human solid tumors were included.ResultsIt showed that patients with higher expression of CXCR3 had significantly shorter OS (pooled hazard ratio =2.315, 95% CI: 1.162–4.611, P=0.017). In addition, higher CXCR3 expression was associated with distant metastasis (yes vs no: pooled relative ratio [RR] =1.828, 95% CI: 1.140–2.931, P=0.012) in solid tumors and indicated advanced tumor stage (III/IV vs I/II, RR =2.656, 95% CI: 1.809–3.900, P<0.001) and lymph node metastasis (yes vs no: RR =2.28, 95% CI: 1.61–3.25, P<0.001) in colorectal cancer.ConclusionOur study highlights the role of CXCR3 as a potential prognostic marker and a promising therapeutic target in solid tumors.
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