Abstract
CXCL14: the Swiss army knife chemokine.
Highlights
Since their discovery in the late 1980s, chemokines have been hailed as major contributors in the recruitment and function of immune cells in health and in all types of inflammatory diseases
In a recent study that we wish to highlight here, we have shown evidence that CXCL14 contributes to killing lung bacterial pathogens both in vivo and in vitro [2]
CXCL14 homologs in all vertebrates differ from other chemokines by an abnormally short amino-terminus of only two amino acids located before the first disulfide bridge and normally required for triggering G protein-coupled receptors
Summary
Since their discovery in the late 1980s, chemokines have been hailed as major contributors in the recruitment and function of immune cells in health and in all types of inflammatory diseases. In a recent study that we wish to highlight here, we have shown evidence that CXCL14 contributes to killing lung bacterial pathogens both in vivo and in vitro [2]. CXCL14 homologs in all vertebrates differ from other chemokines by an abnormally short amino-terminus of only two amino acids located before the first disulfide bridge and normally required for triggering G protein-coupled receptors.
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