Abstract
CX3CR1 in multiple sclerosis.
Highlights
We provided evidence that the knockout of CX3CR1 blocked the clearance of myelin debris by microglia, which greatly affected the integrity of axons and myelin sheaths, preventing proper remyelination
These results highlight the crucial role played by CX3CR1 in myelin removal and show that there can be no efficient remyelination following a primary demyelinating insult if myelin clearance by microglia is impaired
Multiple Sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) associated with prominent demyelination, which impairs the conduction of signals along axons
Summary
Ex. Med, we provided evidence that the knockout of CX3CR1 blocked the clearance of myelin debris by microglia, which greatly affected the integrity of axons and myelin sheaths, preventing proper remyelination. These results highlight the crucial role played by CX3CR1 in myelin removal and show that there can be no efficient remyelination following a primary demyelinating insult if myelin clearance by microglia is impaired. Cells of the mononuclear phagocytic system, including monocytederived macrophages (MDM) and microglia, are actively implicated in the clearance of myelin debris.
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