Abstract
New inhibitors of palmitoyl-CoA oxidation are based on the introduction of nitrogen heterocycles in the ‘Western Portion’ of the molecule. SAR studies led to the discovery of CVT-4325 (shown), a potent FOXi (IC 50 = 380 nM rat mitochondria) with favorable PK properties ( F = 93%, t 1/2 = 13.6 h, dog).
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