Abstract
Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS2, including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models. The results show that MoS2 undergoes hydrolysis slowly in aqueous solutions without adverse biological effects. We also present a class of MoS2-based bioabsorbable and multi-functional sensor for intracranial monitoring of pressure, temperature, strain, and motion in animal models. Such technology offers specific, clinically relevant roles in diagnostic/therapeutic functions during recovery from traumatic brain injury. Our findings support the broader use of 2D materials in transient electronics and qualitatively expand the design options in other areas.
Highlights
Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner
The most sophisticated transient technologies use silicon nanomembranes (Si NMs), due to an advantageous combination of transport properties and nanoscale thicknesses, the latter of which allows their complete dissolution in water or biofluids due to hydrolysis over timescales that are relevant for degradation in the environment or the body[14]
Monolayer MoS2 crystals with sharp triangular corners and grain size of 5–25 μm were synthesized on SiO2/Si substrates using atmospheric pressure chemical vapor deposition (APCVD) (Supplementary Fig. 1a), as described in the Methods Section. mTFihgoe.d1ecb)h)aa.rnSaduccte4hr0ia2stscicmmRa−la1l md(iaofnfuetr-peoenfa-ckpeslainnarefereAaq1tuge3mn8c2oydc(me2)0−(1cSmu(pi−np1-l)pelmbaenetenwteaEer2nyg the two Raman peaks is consistent with the monolayer nature of the crystals[30]
Summary
Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. We present a class of MoS2-based bioabsorbable and multi-functional sensor for intracranial monitoring of pressure, temperature, strain, and motion in animal models Such technology offers specific, clinically relevant roles in diagnostic/therapeutic functions during recovery from traumatic brain injury. Transient electronics is a class of technology defined by its ability to physically disappear or disintegrate in a controlled manner and/or at a specified time Systems of this type can be designed to dissolve in water or biofluids, in a biocompatible and environmentally benign fashion, after a stable operating period[1,2]. Dielectric polymers include poly(vinyl alcohol), polyvinylpyrrolidone, poly(lactic-co-glycolic acid) (PLGA), polylactic acid, and polycaprolactone, as well as biopolymers such as cellulose and silk Such materials offer appealing attributes as substrates and encapsulation layers[11]. Developing transient semiconductors that simultaneously minimize, to a fundamental level, the total material content, and maximize the mechanical robustness, the electrical performance characteristics and the optical transparency represents an important direction for research in this emerging field
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