Abstract
An important breakthrough in the search for a drug to prevent chemotherapy-induced hair loss has been reported by Stephen Davis and colleagues (Science 2001, Vol. 291, 134–137). Many anti-tumour agents cause hair loss because they target rapidly dividing cells, including those of the hair follicle. Davis and co-workers showed that an inhibitor of cyclin-dependent kinase 2, which drives the cell cycle, blocked hair follicle cell division and prevented chemotherapy-induced hair loss in neonatal rats. These results offer the hope of a treatment for one of the distressing side-effects of anti-cancer therapies. RC
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