Abstract
Glaucoma is the second most prevalent eye condition, after cataracts, known to cause irreversible blindness in the world. Currently, the only modifiable risk factor for the progression of this disease is intraocular pressure (IOP). This article aims to evaluate the hypotensive potential of topical calcium channel blockers in glaucoma management, based on our current knowledge about this disease. A comprehensive literature search was conducted on Medline, PubMed, and Google Scholar databases in April 2013. Search temporal limits included articles published from 1996 to 2013 with the purpose of providing the most recent evidence. Studies were queried using the following keywords in various combinations: glaucoma, calcium channel blockers, glaucomatous optic neuropathy, neuroprotection, topical calcium channel blockers. The articles of high or medium clinical and preclinical relevance were selected for review. Multiple studies have shown the relevancy and effectiveness of topical calcium channel blockers as an alternative hypotensive therapy in glaucoma management. Taken into account that not all calcium channel blockers are equally effective, the challenge for future research will be to determine the best type of calcium channel blocker.
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