Abstract
From the Sections of Rheumatology and Dermatology. Department of Medicine, The Medical College of Wisconsin, Milwaukee. Wisconsin; and the Cutaneous Immunopathology and Research Services, Veterans Administration Center, Wood, Wisconsin. This study was supported in part by research grants A114550, AM00483 and AM29074 from the NIH. U.S. Public Health Service, and by a grant from the Veterans Administration. Requests for reprints should be addressed to Dr. Franklin Kozin. Division of Rheumatology. The Medical College of Wisconsin, 8709 West Wisconsin Avenue, Milwaukee, Wisconsin 53226. Manuscript accepted July 12. 1979. * Present address: 1030 President Ave. Fall River, Massachusetts 02720. The presence of immunoglobulin and complement in the cutaneous blood vessels of clinically uninvolved forearm skin was studied in 70 patients with rheumatoid arthritis, using immunofluorescent techniques. Patients with evidence of these immune deposits had a greater prevalence of circulating immune complexes, vasculitic skin lesions, subcutaneous nodules, high titer rheumatoid factor and other findings suggestive of active vasculitis. Biopsy of uninvolved forearm skin may be a useful tool in asses&g those patients with rheumatoid arthritis suspected of having a systemic vasculitis.
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