Abstract
An extremely rare case of sinus histiocytosis of the non-Langerhans cell histiocytoses type is described in 55-year-old patient with isolated localization of cutanious lesion on the right cheek without involvement of nodular structures. Main skin lesion was an erythematous-cyanotic node with multiple milia-like lesions on the top of it. Histologically revealed feature was a large number of plasma cells, besides phenomenon of emperipolesis was described, which was first falsely perceived by pathologists as phagocytosis. In immu-nohistochemistry assay the changes were characterized by proliferation of large polygonal histiocytes with accumulation of pentalamellar markers in its cytoplasm (protein S-100, CD68).
Highlights
Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation L’va Tolstogo str., bldng 6–8, Saint Petersburg, 197022, Russian Federation
An extremely rare case of sinus histiocytosis of the non-Langerhans cell histiocytoses type is described in 55-year-old patient with isolated localization of cutanious lesion on the right cheek without involvement of nodular structures
Revealed feature was a large number of plasma cells, besides phenomenon of emperipolesis was described, which was first falsely perceived by pathologists as phagocytosis
Summary
Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation L’va Tolstogo str., bldng 6–8, Saint Petersburg, 197022, Russian Federation. Описан чрезвычайно редкий случай синусного гистиоцитоза нелангергансового типа у пациентки 55 лет с изолированной локализацией процесса на коже правой щеки, без вовлечения нодулярных структур. При патоморфологическом исследовании особенностью являлось наличие большого количества плазматических клеток, кроме этого описан феномен эмпериполеза, который сначала был ошибочно воспринят морфологами как «фагоцитоз». Ключевые слова: синусный гистиоцитоз кожи нелангенгарсового типа, кожная форма, эмпериполез, диагностика, иммуногистохимическое (ИГХ) исследование биоптата
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