Abstract
Cutaneous Rosai-Dorfman Disease (CRDD) is an uncommon benign histiocytosis of unknown etiology. CRDD is oftentimes misdiagnosed because it has variable clinical manifestations, particularly in the absence of lymphadenopathy. We report a case of a 23-year-old African American woman presenting with clustered nodular plaques on her right thigh, buttocks, back, and chest for the past two years. History, clinical, histopathological, and immunochemistry findings corresponded with CRDD, and as such, she was treated with halobetasol propionate 0.05% cream twice daily.
Highlights
Rosai-Dorfman Disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is a benign, self-limited proliferation of histiocytosis, first described by Rosai and Dorfman in 1969.1-3 RDD may involve the skin secondary to multi-organ involvement, or it may solely involve the skin without any other organ involvement
The disease is classified as Cutaneous Rosai-Dorfman Disease (CRDD).[1,2,3,4,5]
We report the case of a biopsy and immunohistochemistry proven CRDD, in a young African American woman
Summary
Rosai-Dorfman Disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is a benign, self-limited proliferation of histiocytosis, first described by Rosai and Dorfman in 1969.1-3 RDD may involve the skin secondary to multi-organ involvement, or it may solely involve the skin without any other organ involvement. In the latter scenario, the disease is classified as Cutaneous Rosai-Dorfman Disease (CRDD).[1,2,3,4,5] CRDD is believed to be a distinct entity because of its unique epidemiologic pattern and the absence of systemic manifestations.[4,5] It is considered a rare entity, with only a few cases reported in the literature.[5] We report the case of a biopsy and immunohistochemistry proven CRDD, in a young African American woman. New lesions developed on her chest, back, and buttocks, though some resolved
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