Abstract
In a recent report, the isolation and characterization of meningococcal polysaccharides of serogroups A, B, and C have been described [1]. Immunization of human volunteers with the purified polysaccharide of groups A and C meningococci resulted in the development of antibodies as measured by hemagglutination (HA) , bactericidal assay, and fluorescent antibody techniques [2, 3]. In these studies a dose of 50 ig was administered intracutaneously. Local skin reactions occurred in all recipients of vaccine, but these were minimal and disappeared within 48 hr. No systemic reactions were observed. The current studies were undertaken with the
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