Abstract
We describe the case of a patient who received the diagnosis of squamous cell carcinoma of the radio-treated skin of the sacrococcygeal region where an extramedullary plasmacytoma had been identified one year before. We think that the plasmacytoma was born by a malignant transformation of a host-inflammatory reaction to a not-detected epithelial tumor. It can also hypothesized that plasma-cell dyscrasia or post-radiation infiammatory reaction had promoved the squamous cell carcinoma occurrence.
Highlights
Extramedullary plasmacytoma (EMP) is a plasma-cell tumour that origins from soft tissues
We describe the case of a patient who received the diagnosis of squamous cell carcinoma of the radio-treated skin of the sacrococcygeal region where an extramedullary plasmacytoma had been identified one year before
What we present here is an unusual case of cutaneous EMP associated with squamous cell carcinoma (SCC) localized at sacrococcygeal region
Summary
Extramedullary plasmacytoma (EMP) is a plasma-cell tumour that origins from soft tissues. Diagnosis requires a biopsy-proven monoclonal plasma cell infiltration of a single site without evidence of systemic disease (bone marrow involvement, hypercalcemia, lytic bone lesions, anemia or renal disease); a monoclonal paraprotein is detected in the serum and/or urine in fewer than 25% of patients [Dimopoulos, 2002; UKMF, 2004; Weber, 2005]. The patient was further investigated: the absence of bone marrow plasma cell infiltration, lytic bone lesions at skeletal survey, hypercalcemia, anemia and renal disease supported the diagnosis of solitary, cutaneous EMP. The removed material was addressed to pathology examination, which excluded the relapse of the plasma cell disease or the presence of other neoplastic lesions, exclusively confirming an inflammatory process.
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