Cutaneous Nevi in Down Syndrome Patients: Prospective study

Abstract

Background: Down Syndrome (DS) has been described in association with various dermatoses,however, there is scanty information in the literature regarding the frequency of cutaneous nevi among Down syndrome patients. The objective of the study: To define the frequency of different cutaneousnevi in DS patients, andto precise their different phenotypes. Patients and methods: we prospectively examined 180 Down syndrome patients. All patients underwent full body skin examination noting the type, number, size, and distribution of different nevi. Results: Different types of nevi were noted among Down syndrome patients; café au lait macules, melanocytic nevocellular nevi, and Mongolian spot were the most frequent ones. Juvenile elastoma, Becker’s nevus, nevus spilus, labial melanocytic macule, and capillary vascular malformation were also seen. Conclusion: Various types of cutaneous nevi not previously described in Down syndrome, was observed in our patients such as Becker’s nevus, nevus spilus and Juvenile elastoma.