Abstract
The present study reports the case of a 71-year-old female with metastatic adenocarcinoma of the skin who developed tumor lysis syndrome (TLS) upon admittance to the First Affiliated Hospital of Liaoning Medical University (Jinzhou, China). The patient presented to the hospital due to multiple subcutaneous nodules, lethargy and weakness, but succumbed without any cancer therapy. Metastases to the skin from solid carcinomas are uncommon, and several studies have reported patients with minimal primary symptoms despite extensive metastatic skin disease. However, few cases were accompanied with spontaneous TLS at the time of presentation. TLS may be a severe complication during the therapy for hematological and oncological diseases. Although spontaneous TLS in internal tumors has been reported, it is extremely rare. The present study highlights the fact that multiple subcutaneous metastases may occur with the symptoms of spontaneous TLS, and may be key for the early recognition of this syndrome.
Highlights
Case reportSkin metastasis and tumor lysis syndrome (TLS) represent independent prognostic factors of poor survival in patients with malignant tumors
The present study reports a case of cutaneous metastatic adenocarcinoma with TLS that showed extremely rapid progression
A 71‐year‐old female was admitted to the First Affiliated Hospital of Liaoning Medical University (Jinzhou, China) with multiple, red‐colored, firm, non‐tender subcutaneous nodules (0.5‐6 cm in diameter) over the anterior chest wall, back, arms, inguinal region, neck, tongue and upper eyelid that had been present for 3 weeks
Summary
The patient presented with a 2‐year history of slight postmenopausal bleeding and an 11‐month history of a mild sensation of suppression in the chest. The latter two symptoms were so mild that the patient had previously paid no attention to them. WANG et al: MULTIPLE CUTANEOUS METASTASES WITH SPONTANEOUS TUMOR LYSIS SYNDROME of bicarbonate radical, high doses of allopurinol, calcium and potassium‐binders were administered intravenously. The patient was referred to the First Affiliated Hospital of Liaoning Medical University for treatment of metastatic disease and due to serious weakness. The renal parameters were increased as follows: Creatinine, 112.87 μmol/l; urea, 21.22 mmol/l; uric acid, 616.00 μmol/l; and bicarbonate radical, 19.60 mmol/l.
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