Abstract
Itch is defined as an unpleasant sensation that stimulates the scratch reflex. While acute itch, such as from an insect bite, is protective and serves as a warning signal for potential tissue damage, chronic itch significantly impairs quality of life. This condition is still poorly understood and lacks universally effective treatments. Uncovering the cellular and molecular mechanisms of chronic itch is crucial for the development of anti-itch therapies. Skin is the largest sensory organ in which itch sensation is initiated. Currently, knowledge of itch signaling pathways in the skin has focused on (1) neuroimmune crosstalk in itch and inflammation in the skin; (2) skin-expressed ion channels that regulate itch signaling; and (3) skin-derived antimicrobial peptides that act as endogenous pruritogens.
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