Cutaneous Intravascular/Angiotropic Lymphoma Following a Septic Shock Episode. Case Report and Literature Review

Abstract

Angiotropic lymphoma is a rare aggressive disease characterized by exclusive or predominant accumulation of malignant lymphoid cells within the lumen of small arteries, veins and capillaries. We describe a 74-year-old female patient who presented at the department of dermatology with widespread cutaneous telangiectasia and generalized edema. No neurologic symptoms were present during the course of these clinical manifestations. After close-up examination and further laboratory and radiological studies, the final diagnosis of cutaneous intravascular lymphoma was made in the histopathological report. Immunochemistry evaluation confirmed a B-cell subtype. Diagnosis of this rare disease, in most cases, is achieved by surgical biopsy. The biopsy and immunohistochemistry have increased the chances of an ante mortem diagnosis. Afterward, the patient was referred to Hematologic Department to follow the combined chemotherapy treatment, which resulted to be successful, and the cutaneous lesions began to disappear