Abstract
The cutaneous sensation of itch is common to human and nonhuman primates. Developments in human itch research have revealed molecular underpinnings that span immune and neural networks within the skin and the nervous system. This work presents the differentially expressed genes (DEGs) and immunohistochemistry profile of primates with itch and provides an interesting comparison with the known itch pathways in humans as well as insight into the mediators that represent promising therapeutic targets.
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