Abstract
: Angiosarcoma developing after mastectomy with or without postoperative radiotherapy for breast carcinoma has been well described. All tumors were associated with chronic lymphedema, and in those receiving radictherapy, most arose outside the field of radiation. Angiosarcoma arising within the field of irradiation after lumpectomy and radiotherapy is rare. Only 21 cases have been reported. A cutaneous angiosarcoma developed in the breast of an 82-yearold woman, 3 years and 5 months after breast-conserving surgery and radiation for ductal carcinoma. The tumor presented as multiple skin nodules which histologically showed a poorly differentiated neoplasm with prominent epithelioid features. An initial diagnosis of recurrent ductal carcinoma was given. However, review of the neoplasm exhibited features of vascular differentiation with positivity for the endothelial markers factor VII and CD34, diagnostic of high-grade angiosarcoma. This complication raises the question of routine radiotherapy following lumpectomy and whether elderly patients should be soared postoperative radiation.
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