Abstract
IntroductionSeveral cases of sarcoidosis following treatment with interferon-α have been reported in the literature, but those following interferon-β are very rare. We report the case of a patient with multiple sclerosis who developed pulmonary and cutaneous sarcoidosis following treatment with Betaseron® (interferon-β-1b).Case presentationA 33-year-old Caucasian woman with a history of multiple sclerosis, treated with interferon-β-1b for 2.5 years developed erythema nodosum in her lower limbs, a breast abscess, and unilateral adenopathy of her left lung. A skin biopsy confirmed sarcoidosis. After the discontinuation of interferon-β-1b and treatment with indomethacin and prednisolone, she recovered.ConclusionsSarcoidosis is considered one of the most common multiple sclerosis imitators with involvement of the central nervous system. However, although rare, sarcoidosis can develop following treatment with interferon-β-1b and should be considered in patients with multiple sclerosis treated with beta-interferons who develop pulmonary or extra-pulmonary manifestations of sarcoidosis. Interferon-β-1b discontinuation is the first and most important step in the treatment of such cases followed by treatment with corticosteroids.
Highlights
Several cases of sarcoidosis following treatment with interferon-α have been reported in the literature, but those following interferon-β are very rare
Rare, sarcoidosis can develop following treatment with interferon-β-1b and should be considered in patients with multiple sclerosis treated with beta-interferons who develop pulmonary or extra-pulmonary manifestations of sarcoidosis
Interferon-β-1b discontinuation is the first and most important step in the treatment of such cases followed by treatment with corticosteroids
Summary
Sarcoidosis is one of the differential diagnoses of MS. The present case demonstrates that treatment with IFN-β-1b can result in the development of sarcoidosis in patients with MS. In patients with respiratory or cutaneous symptoms, IFN-β-induced sarcoidosis should be considered among differential diagnoses. Cases of IFN-β-induced sarcoidosis are therapeutically responsive to the discontinuation of the IFN-β and treatment with corticosteroids. Consent Written informed consent was obtained from the patient for publication of this case report and accompanying images. Authors’ contributions MAS, ANM, MO, MM, and FK prepared the text and collected all the medical data, reviewed the literature, provided suitable references, and assisted in the draft version of the paper. MAS and FK reviewed and interpreted magnetic resonance imaging and histopathology reports, collected clinical data, and assisted with preparation of the manuscript.
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